Arenavirus Variations Due to Host-Specific Adaptation
نویسندگان
چکیده
منابع مشابه
Arenavirus Variations Due to Host-Specific Adaptation
Arenavirus particles are enveloped and contain two single-strand RNA genomic segments with ambisense coding. Genetic plasticity of the arenaviruses comes from transcription errors, segment reassortment, and permissive genomic packaging, and results in their remarkable ability, as a group, to infect a wide variety of hosts. In this review, we discuss some in vitro studies of virus genetic and ph...
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The innate response to infection by an Old World arenavirus is initiated and mediated by extracellular and intracellular receptors, and effector molecules. In response, the invading virus has evolved to inhibit these responses and create the best environment possible for replication and spread. Here, we will discuss both the host's response to infection with data from human infection and lesson...
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Adaptation is a task of case-based reasoning systems that is largely domain-dependant. This motivates the study of adaptation knowledge acquisition (AKA) that can be carried out thanks to learning processes on the variations between cases of the case base. This paper studies the representation of these variations and the impact of this representation on the AKA process, through experiments in a...
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Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively. Given the human health threat that arenaviruses represent and the lack of a specific and safe chemotherapy, the search for effective antiviral compounds is a continuous demanding effort. S...
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ژورنال
عنوان ژورنال: Viruses
سال: 2013
ISSN: 1999-4915
DOI: 10.3390/v5010241